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1.
Bol. Asoc. Méd. P. R ; 93(1/12): 3-8, Jan.-Dec. 2001.
Article in English | LILACS | ID: lil-411255

ABSTRACT

Colorectal cancer (CRC) incidence in Puerto Rico has increased prodigiously since incidence figures were first recorded in 1950. Implications for hereditary nonpolyposis colorectal cancer (HNPCC) in concert with this increased CRC incidence are discussed. A family with the Amsterdam-positive criteria of the Lynch syndrome II variant, identified in the eastern area of Puerto Rico, is described. As far as we can determine, this is the first such report of this disorder in Puerto Rico


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Colorectal Neoplasms, Hereditary Nonpolyposis/epidemiology , Adjuvants, Immunologic/administration & dosage , Adjuvants, Immunologic/therapeutic use , Antimetabolites, Antineoplastic/administration & dosage , Antimetabolites, Antineoplastic/therapeutic use , Drug Therapy, Combination , Follow-Up Studies , Fluorouracil/administration & dosage , Fluorouracil/therapeutic use , Incidence , Levamisole/administration & dosage , Levamisole/therapeutic use , Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis , Colorectal Neoplasms, Hereditary Nonpolyposis/drug therapy , Colorectal Neoplasms, Hereditary Nonpolyposis/genetics , Colorectal Neoplasms/epidemiology , Pedigree , Puerto Rico/epidemiology , Time Factors
2.
Bol. Asoc. Méd. P. R ; 90(7/12): 140-143, Jul.-Dec. 1998.
Article in English | LILACS | ID: lil-411360

ABSTRACT

During the last 41 years cancer of the colon in Puerto Rico has markedly increased as reported by the Puerto Rico Cancer Registry. The etiology of this increase remains elusive, but possibilities include an increase in reporting new cases, dietary modifications, exposure to carcinogens, as well as an hereditary predisposition. The importance of Hereditary Nonpolyposis Colorectal Cancer (HNPCC) in Puerto Rico, its molecular genetics, diagnostic criteria, and management will be discussed


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Colorectal Neoplasms, Hereditary Nonpolyposis/epidemiology , Colorectal Neoplasms/epidemiology , Cohort Studies , Diet , Colorectal Neoplasms, Hereditary Nonpolyposis/genetics , Colorectal Neoplasms/etiology , Colorectal Neoplasms/genetics , Pedigree , Puerto Rico/epidemiology , Registries , Risk Factors
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